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Synthesis of Isoxazoline N-Oxides via [Hydroxy(tosyloxy)iodo]benzene (HTIB)-Mediated Oxidative N−O Coupling

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posted on 2011-01-21, 00:00 authored by Mustafa J. Raihan, Veerababurao Kavala, Pateliya Mujjamil Habib, Qiao-Zhi Guan, Chun-Wei Kuo, Ching-Fa Yao
An HTIB mediated oxidative N−O coupling strategy for the synthesis of some isoxazoline N-oxide derivatives from β-hydroxyketoximes is described, along with a comparative study of the efficiency of N−O coupling in two different solvents. A plausible mechanism for the conversion is proposed.

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