Synthesis of Isocoumarins from Cyclic 2‑Diazo-1,3-diketones and Benzoic Acids via Rh(III)-Catalyzed C–H Activation and Esterification
datasetposted on 20.01.2017 by Cheng Yang, Xinwei He, Lanlan Zhang, Guang Han, Youpeng Zuo, Yongjia Shang
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
A mild and efficient Rh(III)-catalyzed C–H activation/esterification reaction for the synthesis of isocoumarins has been developed. This procedure uses readily available benzoic acids and cyclic diazo-1,3-diketones as starting materials and involves domino intermolecular C–H activation in combination with intramolecular esterification to give the corresponding isocoumarins in moderate to excellent yields. This process provides a facile approach for the construction of isocoumarins containing various functional groups that does not require any additives.