posted on 2019-12-04, 15:36authored byTatyana
A. Tikhonova, Konstantin A. Lyssenko, Igor V. Zavarzin, Yulia A. Volkova
The three-component reaction of 2,2′-biphenyldiamines
with
2-chloroacetic acid derivatives and elemental sulfur was developed
for the practical synthesis of unknown 2-carboxamide-substituted dibenzo[d,f][1,3]diazepines. This protocol is distinguished
by efficiency in water and good tolerance to functional groups and
can be adapted to a large-scale synthesis. The chemoselective preparation
of a variety of 2-S,N,O-substituted dibenzo[d,f][1,3]diazepines
was accomplished using the developed method.