posted on 2018-09-10, 00:00authored byDeqiang Liang, Qishan Dong, Penghui Xu, Ying Dong, Weili Li, Yinhai Ma
With an unactivated double bond as the radical acceptor, allyl
amines underwent a metal-free trifluoromethylation/cyclization cascade
with CF3SO2Na (Langlois’ reagent), affording
CF3CH2-containing indolines and tetrahydroisoquinolines,
whose practical syntheses are significant challenges. This protocol
features mild conditions, low cost, and a broad substrate scope.