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Synthesis of CF3CH2‑Containing Indolines by Transition-Metal-Free Aryltrifluoro­methylation of Unactivated Alkenes

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posted on 2018-09-10, 00:00 authored by Deqiang Liang, Qishan Dong, Penghui Xu, Ying Dong, Weili Li, Yinhai Ma
With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CF3SO2Na (Langlois’ reagent), affording CF3CH2-containing indolines and tetrahydro­isoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.

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    The Journal of Organic Chemistry

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