American Chemical Society
ol6b03763_si_005.cif (15.38 kB)

Synthesis of 6H‑Benzo[c]chromenes via Palladium-Catalyzed Intramolecular Dehydrogenative Coupling of Two Aryl C–H Bonds

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posted on 2017-02-01, 13:49 authored by Dong-Dong Guo, Bin Li, Da-Yu Wang, Ya-Ru Gao, Shi-Huan Guo, Gao-Fei Pan, Yong-Qiang Wang
The palladium-catalyzed intramolecular C–H/C–H coupling reaction of two simple arenes to generate 6H-benzo­[c]­chromenes has been reported for the first time. The approach features broad substrate scope and good tolerance of functional groups and uses molecular oxygen as the terminal oxidant. The high efficiency of the approach is verified by concise total synthesis of natural product cannabinol.