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Synthesis of 3‑Azabicyclo[m.2.0] Ring Systems via a Copper-Catalyzed Cascade Reaction of Diazo Compounds with 1,n‑Allenynes

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posted on 03.03.2020, 16:06 by Min He, Nuan Chen, Lala Liu, Yuqi Zhu, Qing Li, Hongguang Li, Ming Lang, Jian Wang, Shiyong Peng
A copper-catalyzed cascade reaction of diazo compounds with 1,n-allenynes (n = 6,7) was reported, which provides efficient access to various functionalized 3-azabicyclo­[m.2.0] frameworks (m = 5,6) in moderate to excellent yields under mild reaction conditions. The reaction proceeds through intermolecular cross-coupling to form bisallene intermediates, followed by subsequent intramolecular [2+2] cycloaddition.