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Synthesis of 2,4-Diiodoquinolines via the Photochemical Cyclization of o-Alkynylaryl Isocyanides with Iodine

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posted on 18.02.2011, 00:00 by Takenori Mitamura, Akiya Ogawa
Upon photoirradiation of o-alkynylaryl isocyanides in the presence of iodine, the intramolecular cyclization of o-alkynylaryl isocyanides proceeds to afford the corresponding 2,4-diiodoquinolines in good yields. 2,4-Diiodoquinolines can be employed in transition metal-catalyzed cross-coupling reactions.