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Synthesis and N‑Methyl‑d‑aspartate (NMDA) Receptor Activity of Ketamine Metabolites
dataset
posted on 2017-08-22, 20:14 authored by Patrick J. Morris, Ruin Moaddel, Panos Zanos, Curtis E. Moore, Todd Gould, Carlos A. Zarate, Craig J. ThomasKetamine
is rapidly metabolized in the human body to a variety
of metabolites, including the hydroxynorketamines. At least
two hydroxynorketamines have significant antidepressant action
in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12
hydroxynorketamines and their binding affinity to the NMDA receptor
is presented here.
