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Synthesis and Synthetic Application of Chloro- and Bromofuroxans

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posted on 13.04.2020, 15:48 by Ryosuke Matsubara, Akihiro Ando, Hayu Hasebe, Hojin Kim, Takao Tsuneda, Masahiko Hayashi
Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods. Herein, we report a new synthetic approach for the synthesis of chloro- and bromofuroxans. The starting materials were dichloro- and dibromofuroxans, and the substituents were directly introduced to the furoxan ring in a modular fashion. The synthesized monohalofuroxans served as substrates for the installation of a second substituent to prepare further functionalized furoxans.