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Synthesis and Optical Resolution of 9,9‘-Spirobifluorene-1,1‘-diol

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posted on 08.07.2004, 00:00 by Xu Cheng, Guo-Hua Hou, Jian-Hua Xie, Qi-Lin Zhou
9,9‘-Spirobifluorene-1,1‘-diol (SBIFOL) was conveniently synthesized from 1,2-dibromobenzene and 3-bromoanisole in high yield. Both enantiomers of SBIFOL were obtained in 99% ee by inclusion resolution with 2,3-dimethoxy-N,N,N,N-tetracyclohexylsuccinamide. The absolute configurations were determined by X-ray analysis of a single crystal of molecular complex.