Synthesis and Characterization of New V1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers
datasetposted on 13.07.2021, 20:31 by Zsolt Szeleczky, Zoltán Szakács, Éva Bozó, Ferenc Baska, Krisztina Vukics, Sándor Lévai, Krisztina Temesvári, Elemér Vass, Zoltán Béni, Balázs Krámos, Ildikó Magdó, Csaba Szántay, János Kóti, Katalin Domány-Kovács, István Greiner, Imre Bata
A new class of selective vasopressin receptor 1A (V1A) antagonists was identified, where “methyl-scan” was performed around the benzene ring of the 5-hydroxy-triazolobenzazepine core. This led to the synthesis of two 10-methyl derivatives, each possessing a chiral axis and a stereogenic center. The four atropisomeric stereoisomers (involving two enantiomer pairs and atropisomeric diastereomers) could be successfully isolated and spectroscopically characterized. According to the in vitro pharmacological profiles of the compounds, the human V1A receptor has a strong preference toward the isomers having an aR axial chirality, the most active isomer being the aR,5S isomer. Furthermore, the structure–activity relationships obtained for the isomers and for the newly synthesized analogues could be tentatively explained by an in silico study.
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benzeneanalogueisomerstereogenicchiralitycompoundstereoisomerAtropisomericaxisatropisomericSeparationCompoundmethyl-scanisomersAntagonistSynthesiprofileenantiomerrelationshipdiastereomervasopressin receptor 1V 1preferenceantagonistcenterchiralCharacterization5- hydroxy-triazolobenzazepine coreNew V 1Stereoisomer10- methyl derivativessilicospectroscopicallysynthesis