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Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

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posted on 13.12.2012, 00:00 authored by Eva Torres, Roser Fernández, Stéphanie Miquet, Mercè Font-Bardia, Evelien Vanderlinden, Lieve Naesens, Santiago Vázquez
The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner–Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

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