ic502274b_si_002.cif (262.26 kB)

Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based β‑Ketoamine Ligands

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posted on 15.12.2014, 00:00 by Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Agnese Petrini, Rosario Scopelliti, Catherine M. Clavel, Paul J. Dyson
Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.

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