Structural Impact of Coordinating a Helical 2,6-Pyridyl Diamide with Divalent Metals
datasetposted on 09.11.2006, 00:00 by Adam J. Preston, Judith C. Gallucci, Jon R. Parquette
The structural consequences of coordinating 2,6-bis[2-((4S)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl)phenyl]carbamoylpyridines, 2, with divalent metals such as Cu(II), Ni(II), and Zn(II) are reported. Metal coordination occurs under mild conditions in a manner that preserves the helical bias of the parent ligand in the solid state and in solution. 1H NMR line-shape analysis indicates that metal coordination increases the helical interconversion barrier, thus rigidifying the dynamic helicity of 2.