ol8016947_si_002.zip (6 MB)
Download file

Stereospecific Total Synthesis of Somocystinamide A

Download (6 MB)
dataset
posted on 16.10.2008, 00:00 by Takashi L. Suyama, William H. Gerwick
The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.

History