American Chemical Society
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Stereospecific Total Synthesis of Somocystinamide A

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posted on 2008-10-16, 00:00 authored by Takashi L. Suyama, William H. Gerwick
The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.