jo6b02793_si_002.cif (250.74 kB)

Stereochemically Defined Various Multisubstituted Alkenes Bearing a Tetrafluoroethylene (−CF2CF2−) Fragment

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posted on 10.01.2017, 00:00 by Yukiho Sakaguchi, Shigeyuki Yamada, Tsutomu Konno, Tomohiro Agou, Toshio Kubota
Highly regio- and stereoselective transformation of commercially available 4-bromo-3,3,4,4-tetrafluoro-1-butene into multisubstituted alkenes having a tetrafluoroethylene fragment through Heck reactions and/or Suzuki–Miyaura cross-coupling reactions was established. Thus, the obtained alkenes underwent a smooth reductive coupling reaction with aldehydes under the influence of MeLi/LiBr-free, affording structurally unprecedented fluorinated materials.