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Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013

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posted on 11.10.2016, 18:21 by Jong Won Kim, Sung-Kyun Ko, Hye-Min Kim, Gun-Hee Kim, Sangkeun Son, Gil Soo Kim, Gwi Ja Hwang, Eun Soo Jeon, Kee-Sun Shin, In-Ja Ryoo, Young-Soo Hong, Hyuncheol Oh, Kyung Ho Lee, Nak-Kyun Soung, Daisuke Hashizume, Toshihiko Nogawa, Shunji Takahashi, Bo Yeon Kim, Hiroyuki Osada, Jae-Hyuk Jang, Jong Seog Ahn
Two new phenylspirodrimane derivatives, stachybotrysin (1) and stachybotrylactone B (2), were isolated from the cultures of the marine-derived fungus Stachybotrys sp. KCB13F013. The structures were determined by analyzing the spectroscopic data (1D and 2D NMR and MS) and chemical transformation, including the modified Mosher’s method and single-crystal X-ray structure analysis. Compound 1 exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.

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