np6b00431_si_002.cif (16.58 kB)
Spiro Meroterpenoids from Ganoderma applanatum
dataset
posted on 2016-12-20, 14:05 authored by Qi Luo, Xiao-Yi Wei, Jing Yang, Jin-Feng Luo, Rui Liang, Zheng-Chao Tu, Yong-Xian ChengSpiroapplanatumines A–Q (1–12, 14–16, 18, and 20), new spiro meroterpenoids
respectively bearing a 6/5/7
or 6/5/5 ring system, along with three known compounds, spirolingzhines
A, B, and D, were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures including absolute
configurations were assigned by using spectroscopic methods, ECD and 13C NMR calculations, and single-crystal X-ray diffraction
analysis. Biological evaluation of all the compounds disclosed that
compounds 7 and 8 inhibited JAK3 kinase
with IC50 values of 7.0 ± 3.2 and 34.8 ± 21.1
μM, respectively.