American Chemical Society
ol900173t_si_001.cif (22.68 kB)

Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

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posted on 2015-12-16, 15:37 authored by Takuya Uchida, Manuela Rodriquez, Stuart L. Schreiber
Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.