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Silver(I) 1,3,5-Triaza-7-phosphaadamantane Coordination Polymers Driven by Substituted Glutarate and Malonate Building Blocks: Self-Assembly Synthesis, Structural Features, and Antimicrobial Properties

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posted on 31.05.2016, 18:48 by Sabina W. Jaros, M. Fátima C. Guedes da Silva, Magdalena Florek, Piotr Smoleński, Armando J. L. Pombeiro, Alexander M. Kirillov
Three new bioactive silver­(I) coordination polymers formulated as [Ag22-PTA)­(μ3-PTA)­(μ2-pga)­(H2O)]n·6H2O (1), [Ag22-PTA)­(μ3-PTA)(Hpmal)2]n·2H2O (2), and [Ag­(μ3-PTA) (Hdmga)]n (3) were self-assembled from Ag2O, 1,3,5-triaza-7-phosphaadamantane (PTA), and a substituted dicarboxylic acid (3-phenylglutaric acid (H2pga), phenylmalonic acid (H2pmal), or 3,3-dimethylglutaric acid (H2dmga)) as an ancillary ligand. Compounds 13 were fully characterized by IR and NMR spectroscopy, ESI-MS(±), elemental analysis, and single-crystal X-ray diffraction, revealing that their architectural and topological diversity is governed by structural modulation of a dicarboxylate building block. The structures vary from a 1D cyclic chain with the SP 1-periodic net (4,4)­(0,2) topology in 2 to distinct 2D metal–organic layers with the cem-d and hcb topologies in 1 and 3, respectively. In addition, compounds 13 exhibit a notable antimicrobial efficiency against a panel of common Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) bacteria and yeast (C. albicans). The best normalized minimum inhibitory concentrations (normalized MIC) of 11–23 nmol mL–1 (for bacterial strains) or 68 nmol mL–1 (for a yeast strain) are shown by compound 2, and the eventual structure–bioactivity correlations are discussed.