Silver-Mediated Oxidative Decarboxylative Trifluoromethylthiolation of Coumarin-3-carboxylic Acids
datasetposted on 23.01.2017, 00:00 by Minghao Li, Jeffrey L. Petersen, Jessica M. Hoover
The introduction of trifluoromethylthio groups into organic compounds, in particular heterocycles, is important because of the prevalence of these structures in medicinally and agriculturally relevant molecules. Herein, the silver-mediated oxidative decarboxylative trifluoromethylthiolation of coumarin-3-carboxylic acids is reported. This methodology utilizes existing carboxylic acid functionalities for the direct conversion to CF3S groups and results in a broad scope of 3-trifluoromethylthiolated coumarins, including analogues of natural products, in moderate to excellent yields.
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prevalence3- trifluoromethylthiolated coumarinscarboxylic acid functionalitiesanalogueSilver-Mediated Oxidative Decarboxylative Trifluoromethylthiolationconversionheterocycleintroductionmethodologysilver-mediated oxidative decarboxylative trifluoromethylthiolationtrifluoromethylthio groupsmedicinallymoleculecompoundcoumarin -3-carboxylic acidsCoumarin -3-carboxylic AcidsCF 3 S groupsHereinyieldscope