Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
datasetposted on 21.04.2016 by Sheng-Ying Hsieh, Jeffrey W. Bode
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Silicon amine protocol (SLAP) reagents for photocatalytic cross-coupling with aldehydes and ketones to form N-unprotected piperazines have been developed. This blue light promoted process tolerates a wide range of heteroaromatic, aromatic, and aliphatic aldehydes and structurally and stereochemically complex SLAP reagents. It provides a tin-free alternative to SnAP (tin amine protocol) reagents for the synthesis of substituted piperazines.