ol6b00005_si_001.cif (21.69 kB)
Download fileShort and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B
dataset
posted on 2016-02-05, 00:00 authored by Dengpeng Song, Zhengshen Wang, Ruoming Mei, Weiwei Zhang, Donghui Ma, Dengyu Xu, Xingang Xie, Xuegong SheThe
first total synthesis of the Myrioneuron alkaloids
(±)-α,β-myrifabral A and B has been accomplished
in only four steps from conveniently available starting materials.
This short synthesis relied on the use of a key tandem Mannich/amidation
reaction to rapidly construct the core framework and two carbon stereocenters.
The synthetic route allows for large scale preparation of these promising
natural products against the hepatitis C virus (HCV).