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Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B

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posted on 05.02.2016, 00:00 authored by Dengpeng Song, Zhengshen Wang, Ruoming Mei, Weiwei Zhang, Donghui Ma, Dengyu Xu, Xingang Xie, Xuegong She
The first total synthesis of the Myrioneuron alkaloids (±)-α,β-myrifabral A and B has been accomplished in only four steps from conveniently available starting materials. This short synthesis relied on the use of a key tandem Mannich/amidation reaction to rapidly construct the core framework and two carbon stereocenters. The synthetic route allows for large scale preparation of these promising natural products against the hepatitis C virus (HCV).