Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Diaporthe sp.
dataset
posted on 2012-10-26, 00:00 authored by Le Yun Zang, Wei Wei, Ye Guo, Ting Wang, Rui Hua Jiao, Seik Weng Ng, Ren Xiang Tan, Hui Ming GeA new sesquiterpenoid, diaporol A (1), possessing
a unique tricyclic lactone framework, eight new drimane sesquiterpenoids,
diaporols B–I (2–9), and the
known compounds 10 and 11 were isolated
from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1–5 were determined by low-temperature (100 K) single-crystal X-ray
diffraction with Cu Kα radiation. The compounds were evaluated
for cytotoxic activity; however, no compound showed significant cytotoxicity
against the tested cell lines at a concentration of 20 μM.
