np3004112_si_005.cif (15.52 kB)

Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Diaporthe sp.

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posted on 26.10.2012, 00:00 by Le Yun Zang, Wei Wei, Ye Guo, Ting Wang, Rui Hua Jiao, Seik Weng Ng, Ren Xiang Tan, Hui Ming Ge
A new sesquiterpenoid, diaporol A (1), possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B–I (29), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 15 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu Kα radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 μM.