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Schisanwilsonenes A−C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana

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posted on 2009-04-24, 00:00 authored by Wen-Hui Ma, Hai Huang, Pei Zhou, Dao-Feng Chen
Three carotane-type sesquiterpenoids, schisanwilsonenes A (1), B (2), and C (3), were isolated from the fruits of Schisandra wilsoniana. Their structures and relative configurations were elucidated on the basis of spectroscopic methods including 2D-NMR techniques, and the structure of 1 was confirmed by a single-crystal X-ray diffraction experiment. Schisanwilsonene A, at 50 μg/mL, exhibited antiviral activity, inhibiting HBsAg and HBeAg secretion by 76.5% and 28.9%.