Scalable Total Synthesis of (−)-Vinigrol
dataset
posted on 2019-02-15, 00:00 authored by Xuerong Yu, Lianghong Xiao, Zechun Wang, Tuoping LuoVinigrol is a structurally
and stereochemically complex natural
product that displays various potent pharmacological activities, including
the capability to modulate TNF-α. A new and efficient synthetic
route toward this natural product has been developed to complete the
asymmetric synthesis of (−)-vinigrol and provide over 600 mg
of material, manifesting the power of macrocyclic stereocontrol and
transannular Diels–Alder reaction.
