Ruthenium(II)-Catalyzed ortho-C–H Chalcogenation of Benzoic Acids via Weak O‑Coordination: Synthesis of Chalcogenoxanthones
datasetposted on 20.04.2017 by Anup Mandal, Suman Dana, Harekrishna Sahoo, Gowri Sankar Grandhi, Mahiuddin Baidya
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A general protocol for direct chalcogenation of inert C–H bonds of (hetero)aromatic carboxylic acids is developed with a ruthenium(II) catalyst using readily available starting materials, offering densely substituted ortho-chalcogenyl aromatic acids in high yields (up to 96%). The strategy avoids the installation of an external directing group, use of metallic oxidants, and features operational simplicity with ample substrate scope. Synthetic application en route to biologically important chalcogenoxanthones is also demonstrated. This work represents the first example of ruthenium(II)-catalyzed direct C–H chalcogenation of benzoic acids.