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Ruthenium-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Aryl and Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes

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posted on 17.06.2011, 00:00 by Motoi Kawatsura, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Hiroaki Tsuji, Toshiyuki Itoh
The regio- and stereoselective addition of carboxylic acids to aryl and trifluoromethyl group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the trifluoromethyl group substituted (E)-enol esters with high regio- and stereoselectivities.