American Chemical Society
jo7b00290_si_003.cif (239.56 kB)

Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides

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posted on 2017-04-24, 00:00 authored by Xiaomei Ding, Manna Huang, Zhou Yi, Dongchen Du, Xinhai Zhu, Yiqian Wan
A general and effective CuI/N′,N′-diaryl-1H-pyrrole-2-carbohydrazide catalyst system was developed for the amination of aryl iodides and bromides at room temperature with good chemoselectivity between −OH and −NH2 groups. Only 5 mol % of CuI and ligands was needed in this protocol to effect the amination of various aryl bromides and aryl iodides with a wide range of aliphatic and aryl amines (1.3 equiv).