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Rhodium(III)-Catalyzed Intermolecular Amidation with Azides via C(sp3)–H Functionalization

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posted on 06.06.2014, 00:00 by Nuancheng Wang, Renhe Li, Liubo Li, Shansheng Xu, Haibin Song, Baiquan Wang
The amidation reactions of 8-methylquinolines with azides catalyzed by a cationic rhodium­(III) complex proceed efficiently to give quinolin-8-ylmethanamine derivatives in good yields via C­(sp3)–H bond activation under external oxidant-free conditions. A catalytically competent five-membered rhodacycle has been isolated and characterized, revealing a key intermediate in the catalytic cycle.