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Rhodium-Catalyzed Directed C–H Cyanation of Arenes with N-Cyano‑N‑phenyl‑p‑toluenesulfonamide

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posted on 24.07.2013, 00:00 by Tian-Jun Gong, Bin Xiao, Wan-Min Cheng, Wei Su, Jun Xu, Zhao-Jing Liu, Lei Liu, Yao Fu
A Rh-catalyzed directed C–H cyanation reaction was developed for the first time as a practical method for the synthesis of aromatic nitriles. N-Cyano-N-phenyl-p-toluenesulfonamide, a user-friendly cyanation reagent, was used in the transformation. Many different directing groups can be used in this C–H cyanation process, and the reaction tolerates a variety of synthetically important functional groups.