posted on 2023-08-21, 14:36authored byKavuri Rupa, Pazhamalai Anbarasan
An efficient rhodium catalyzed [4 + 1]-annulation of o-acylanilines with 3-diazoindoline-2-imines has been successfully
accomplished for the synthesis of spiroindolines in good to excellent
yield. The reaction occurs through formation of N-ylide followed by cyclization and showed good tolerance to various
functional groups. Gram-scale synthesis, diastereoselective construction
of tetrasubstituted indoline, synthesis of spirooxindole, and isolation
of potential intermediates have also been demonstrated.