cs1c01615_si_001.cif (820.37 kB)
Rhodium-Catalyzed Regio‑, Diastereo‑, and Enantioselective Three-Component Carboamination of Dienes via C–H Activation
dataset
posted on 2021-05-24, 12:04 authored by Ruijie Mi, Xuepeng Zhang, Jinlei Wang, Haohua Chen, Yu Lan, Fen Wang, Xingwei LiReported herein is the rhodium-catalyzed
enantioselective three-component
coupling of arene, diene, and dioxazolone that occurs via C–H
activation en route to allyl intermediate. This carboamination reaction
affords chiral allylic amines in 1,2-selectivity, E-selectivity, and enantioselectivity, with electrophilic amination
of the π-allyl species being both regio- and enantio-determining.