posted on 2021-05-24, 12:04authored byRuijie Mi, Xuepeng Zhang, Jinlei Wang, Haohua Chen, Yu Lan, Fen Wang, Xingwei Li
Reported herein is the rhodium-catalyzed
enantioselective three-component
coupling of arene, diene, and dioxazolone that occurs via C–H
activation en route to allyl intermediate. This carboamination reaction
affords chiral allylic amines in 1,2-selectivity, E-selectivity, and enantioselectivity, with electrophilic amination
of the π-allyl species being both regio- and enantio-determining.