American Chemical Society
cs1c01615_si_001.cif (820.37 kB)

Rhodium-Catalyzed Regio‑, Diastereo‑, and Enantioselective Three-Component Carboamination of Dienes via C–H Activation

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posted on 2021-05-24, 12:04 authored by Ruijie Mi, Xuepeng Zhang, Jinlei Wang, Haohua Chen, Yu Lan, Fen Wang, Xingwei Li
Reported herein is the rhodium-catalyzed enantioselective three-component coupling of arene, diene, and dioxazolone that occurs via C–H activation en route to allyl intermediate. This carboamination reaction affords chiral allylic amines in 1,2-selectivity, E-selectivity, and enantioselectivity, with electrophilic amination of the π-allyl species being both regio- and enantio-determining.