posted on 2021-04-20, 11:34authored bySujan Shee, Sabuj Kundu
A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions
utilizing methanol and base, following the borrowing hydrogen strategy.
Diverse ketones, indoles, and arylacetonitriles underwent mono- and
dimethylation selectively up to 99% yield. Remarkably, tandem multiple
methylations were also achieved by employing this catalytic system.