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Rh(III)-Catalyzed Oxidative Coupling of Benzoic Acids with Geminal-Substituted Vinyl Acetates: Synthesis of 3‑Substituted Isocoumarins

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posted on 02.01.2015, 00:00 by Mingliang Zhang, Hui-Jun Zhang, Tiantian Han, Wenqing Ruan, Ting-Bin Wen
The Rh­(III)-catalyzed C–H activation initiated cyclization of benzoic acids with electron-rich geminal-substituted vinyl acetates was described. The reaction was employed to prepare a range of 3-aryl and 3-alkyl substituted isocoumarins selectively.