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Rh(III)-Catalyzed C–H Amidation with N‑Hydroxycarbamates: A New Entry to N‑Carbamate-Protected Arylamines

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posted on 2014-01-17, 00:00 authored by Bing Zhou, Juanjuan Du, Yaxi Yang, Huijin Feng, Yuanchao Li
An unprecedented Rh­(III)-catalyzed direct intermolecular C–H amidation with N-hydroxycarbamates has been developed. Different directing groups, such as pyridine, pyrimidine, pyrazole, and N-OMe oxime, can be employed in this C–H amidation process, providing valuable N-carbamate-protected arylamines (e.g., Cbz, Moz, Ac, Boc, and Fmoc). More importantly, this process may afford a new avenue for intermolecular C–H amidation where readily available N-hydroxycarbamates can be used as the nitrogen source

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