American Chemical Society
ol7b02678_si_003.cif (298.87 kB)

Rh(III)-Catalyzed Diastereodivergent Spiroannulation of Cyclic Imines with Activated Alkenes

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posted on 2017-09-27, 17:33 authored by Bingxian Liu, Panjie Hu, Ying Zhang, Yunyun Li, Dachang Bai, Xingwei Li
Rh­(III)-catalyzed [3 + 2] annulation of cyclic N-sulfonyl or N-acyl ketimines with activated alkenes has been realized, leading to the synthesis of spirocycles with three continuous stereogenic centers. This atom-economic reaction proceeded efficiently under mild and redox-neutral conditions via a C–H activation pathway, and the coupling is diastereodivergent, with the diastereoselectivity being controlled by silver additives.