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Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

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posted on 19.05.2017, 17:23 by Fei Ye, Junting Chen, Tobias Ritter
We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.