American Chemical Society
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Regioselective and Guided C–H Activation of 4‑Nitropyrazoles

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posted on 2014-04-04, 00:00 authored by Viktor O. Iaroshenko, Ashot Gevorgyan, Olena Davydova, Alexander Villinger, Peter Langer
A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.