Regioselective Synthesis of Functionalized Dihydropyrones via the Petasis Reaction
dataset
posted on 2019-12-26, 13:03 authored by Hui Li, Chun-xiao Cui, Guang-hua Zhang, Xiao-qiang Li, Jun YangA novel synthesis methodology for the construction of
functionalized
dihydropyrones has been developed with amines, glyoxylic acid, and
4-substituted-1,2-oxaborol-2(5H)-ols from the Petasis
reaction. Mechanistic investigation indicated the intermolecular SN2 cyclization to provide 3,6-dihydro-2H-pyran-2-ones
(3,6-DHP) and 5,6-dihydro-2H-pyran-2-ones (5,6-DHP)
in one step with moderate to excellent yields.
