Regioselective Iodoazidation of Alkynes: Synthesis of α,α-Diazidoketones

Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN₃), leading to α,α-diazidoketones via the regioselective addition of IN₃ to alkynes. Huisgen cyclization of α,α-diazidoketones generated bis-triazole compounds.