ol5b00395_si_001.cif (25.58 kB)

Regioselective Iodoazidation of Alkynes: Synthesis of α,α-Diazidoketones

dataset

posted on 2015-03-06, 00:00 authored by Noriko Okamoto, Takuya Sueda, Hideki Minami, Yoshihisa Miwa, Reiko Yanada

Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN₃), leading to α,α-diazidoketones via the regioselective addition of IN₃ to alkynes. Huisgen cyclization of α,α-diazidoketones generated bis-triazole compounds.