American Chemical Society
ol5b00726_si_002.cif (37.87 kB)

Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N‑Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals

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posted on 2015-05-15, 00:00 authored by Danbo Xie, Limin Yang, Youqiang Lin, Zhiming Zhang, Dongdong Chen, Xiaofei Zeng, Guofu Zhong
A chiral N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition reaction of imines and oxindole-derived enals was developed for rapid access to spirocylic oxindoles. In most cases, the desired spirocylic oxindole products were obtained in high yields and excellent enantioselectivities with less than 1 h of reaction time.