American Chemical Society
ac3c02211_si_002.xlsx (244.67 kB)

PyMIDA: A Graphical User Interface for Mass Isotopomer Distribution Analysis

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posted on 2024-02-02, 20:43 authored by Naveed Ziari, Marc K. Hellerstein
Mass isotopomer distribution analysis (MIDA) is an analytical technique that measures the synthesis rate of biological polymers using combinatorial probabilities and stable isotope labeling. Over the past few decades, this method has been developed and applied to a wide range of uses that have increased our understanding of metabolism and the etiology and monitoring of disease. There is currently no publicly available piece of software for performing MIDA calculations in a targeted manner without its functionality being limited to a specific use case. We present a cross-platform Python graphical user interface implementation for research to obtain kinetic parameters easily from stable-isotope labeling studies and provide the code and user manual on GitHub.