Protection-Group-Free Semisyntheses of Parthenolide and Its Cyclopropyl Analogue
dataset
posted on 2013-10-18, 00:00 authored by Jing Long, Ya-Hui Ding, Pan-Pan Wang, Quan Zhang, Yue ChenParthenolide
showed extensive bioactivities including selective eradication of
AML stem cells. Herein we report protection-free semisyntheses of
parthenolide and its cyclopropyl analogue (compound 10) from the abundant natural product costunolide with an overall yield
of 55 and 60%, respectively. Compound 10 was more stable
than parthenolide, and it maintained comparable activities against
AML cell lines and AML stem cells. Therefore, compound 10 might be a superior small molecule than parthenolide as a tool for
investigation of cancer stem cell biology.
