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Preparation and Double Michael Addition Reactions of a Synthetic Equivalent of the Nazarov Reagent

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posted on 17.05.2013, 00:00 by Mercedes Amat, Federica Arioli, Maria Pérez, Elies Molins, Joan Bosch
A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with α,β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indolo[2,3-a]quinolizidine lactams to give pentacyclic yohimbinone-type derivatives.

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