jo0c00963_si_002.cif (292.94 kB)

Photocatalyst-Free Singlet Oxygen-Induced Oxygenation: A Strategy for the Preparation of 5‑Cyano-2-pyridones Driven by Blue-Light Irradiation

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posted on 02.06.2020 by Mengmeng Zhang, Hanyang Lan, Nan Li, Qidi Zhong, Hao Zhu, Chunyan Liu, Hongwu Zhao
A mild, catalyst- and metal-free photochemical protocol for the oxygenation of 3-cyano-1,4-dihydropyridines to 5-cyano-2-pyridones was developed. Utilizing molecular oxygen from the air as the oxidant and a cheap blue LED lamp as the light source, a variety of 3-cyano-1,4-dihydropyridines were converted into the corresponding 5-cyano-2-pyridones in moderate to excellent yields. Exploration of the substrate scope revealed that 3-cyano and 4-aryl groups play an important role in the formation of 2-pyridone.