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Phosphine Oxide–Sc(OTf)3 Catalyzed Highly Regio- and Enantioselective Bromoaminocyclization of (E)‑Cinnamyl Tosylcarbamates. An Approach to a Class of Synthetically Versatile Functionalized Molecules

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posted on 19.02.2016, 00:00 by Hongjie Pan, Hu Huang, Weigang Liu, Hua Tian, Yian Shi
A highly regio- and enantioselective bromoaminocyclization of (E)-cinnamyl tosylcarbamates catalyzed by a chiral phosphine oxide–Sc­(OTf)3 complex is described. A wide variety of optically active aryl 5-bromo-1,3-oxazinan-2-ones can be obtained with high yield and enantioselectivity.