jm7b01388_si_002.csv (12.82 kB)
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Version 2 2017-11-10, 17:04
Version 1 2017-11-09, 19:37
dataset
posted on 2017-10-27, 00:00 authored by Jose Antonio Ortega, Laura Riccardi, Elirosa Minniti, Marco Borgogno, Jose M. Arencibia, Maria L. Greco, Anna Minarini, Claudia Sissi, Marco De VivoWe used a pharmacophore
hybridization strategy to combine key structural
elements of merbarone and etoposide and generated new type II topoisomerase
(topoII) poisons. This first set of hybrid topoII poisons shows promising
antiproliferative activity on human cancer cells, endorsing their
further exploration for anticancer drug discovery.
